Kamino H, Tam ST. Immunoperoxidase technique modified by counterstain with azure B as a diagnostic aid in evaluating heavily pigmented melanocytic neoplasms. J Cutan Pathol. 1991 Dec;18(6):436-9. doi: 10.1111/j.1600-0560.1991.tb01381.x. PMID: 1723081.
We had a great Workshop with Thibault Keverrec on Poroid Neoplasms. The recording will be released on 10/22.
I can't join the workshop; the link keeps redirecting. I don't understand what the problem is
Hello everyone 👋
Is it possible to share challenging cases from our practice here?
We had a great 2 hour-long Workshop on Keratoacanthoma with Dr. Richard Carr on 9/17th. It was a really great event that had impact on my practice. The recording is scheduled to be available on Sunday, 9/20th. I highly recommend it.
Melanoma pathology reporting and staging.
During Dermpath in 15 today, I mentioned a paper about how to handle Breslow thickness measurement of melanoma when there is a deeper focus around a sweat duct or hair follicle. This is the publication I was referring to:
Dodds TJ, Lo S, Jackett L, Nieweg O, Thompson JF, Scolyer RA. Prognostic Significance of Periadnexal Extension in Cutaneous Melanoma and its Implications for Pathologic Reporting and Staging. Am J Surg Pathol. 2018 Mar;42(3):359-366. doi: 10.1097/PAS.0000000000000999. PMID: 29240580.
https://pubmed.ncbi.nlm.nih.gov/29240580/
Here's a quote from a later paper by Scolyer and colleagues summarizing the findings of the Dodds et al article. This paper is a gem! Full text free here:
https://www.modernpathology.org/article/S0893-3952(22)00716-5/fulltext
"When there is deep periadnexal extension of melanoma as a “tongue” of tumor that extends much more deeply than the main, more superficial part of the dermal invasive melanoma, it is not recommended that such extension be included in the measurement of tumor thickness, unless this represents the only focus on invasion. Recently published data by Dodds et al. [29] provided evidence based on outcome data that periadnexal extension should not be included in tumor thickness measurements. When periadnexal melanoma represents the only focus of invasion, tumor thickness should be measured from the middle of the adnexal structure from where it has likely risen."
Quoted from:
Scolyer RA, Rawson RV, Gershenwald JE, Ferguson PM, Prieto VG. Melanoma pathology reporting and staging. Mod Pathol. 2020 Jan;33(Suppl 1):15-24. doi: 10.1038/s41379-019-0402-x. Epub 2019 Nov 22. PMID: 31758078.
Here is the reference from our prior live Group case discussion defining how collarettes are formed:
Jacoby RA, Ackerman AB. Is the so-called epidermal collarette formed by epidermal or adnexal epithelium? Am J Dermatopathol. 1982; 4(2):117-24. PMID: 7103013
Key Finding: The study demonstrates that these tissue infoldings are actually formed by epithelial adnexa (adnexal epithelium) rather than the epidermis itself.
Hi everyone!
I'm so glad to be a part of this community🙏
Just a question,
Do you recommend re-excising severly dysplastic nevi with 5 mm margin? (they are completely excised in the planes of examined sections(1-2 mm), young patients, no solar elastosis of course)
131 participants joined the 5-Day Soft Tissue Tumors Challenge so far. How about you? Can you find enough motivation to invest in yourself and complete the Challenge before Friday?
